【病毒外文文獻】2018 Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential ant

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Accepted Manuscript Synthesis biological evaluation and molecular modeling of a novel series of fused 1 2 3 triazoles as potential anti coronavirus agents Konstantina Karypidou Sergio R Ribone Mario A Quevedo Leentje Persoons Christophe Pannecouque Christine Helsen Frank Claessens Wim Dehaen PII S0960 894X 18 30750 9 DOI https doi org 10 1016 j bmcl 2018 09 019 Reference BMCL 26040 To appear in Bioorganic 767 769 23 2 Drosten C G nther S Preiser W Van der Werf S Brodt HR Becker S Rabenau H Panning M 24 Kolesnikova L Fouchier RAM Berger A Burgui re AM Cinatl J Eickmann M Escriou N Grywna K 25 Kramme S Manuguerra JC M ller S Rickerts V St rmer M Vieth S Klenk HD Osterhaus ADME 26 Schmitz H Doerr HW Identification of a novel coronavirus in patients with severe acute respiratory 27 syndrome N Engl J Med 2003 348 1967 1976 DOI https doi org 10 1056 NEJMoa030747 28 3 Kuiken T Fouchier RAM Schutten M Rimmelzwaan GF Van Amerongen G Van Riel D Laman JD De 29 Jong T Van Doornum G Lim W Ling AE 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